Papers with diagnostic reasoning
FAMULUS: Interactive Annotation and Feedback Generation for Teaching Diagnostic Reasoning (D19-3)
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Jonas Pfeiffer, Christian M. Meyer, Claudia Schulz, Jan Kiesewetter, Jan Zottmann, Michael Sailer, Elisabeth Bauer, Frank Fischer, Martin R. Fischer, Iryna Gurevych
| Challenge: | Existing systems for technologyenhanced learning address skills on recalling, explaining, and applying knowledge, e.g., in automatically generated language learning exercises and math word problems. |
| Approach: | They propose to leverage a NLP model to support experts in their further data annotation with automatic suggestions and provide automatic feedback for students. |
| Outcome: | The proposed system improves on two user studies on diagnostic reasoning in medicine and teacher education and can be extended to further use cases. |
DiagnosisArena: Benchmarking Diagnostic Reasoning for Large Language Models (2026.findings-acl)
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Yakun Zhu, Zhongzhen Huang, Linjie Mu, Yutong Huang, Wei Nie, Jiaji Liu, Shaoting Zhang, Pengfei Liu, Xiaofan Zhang
| Challenge: | Existing medical benchmarks for diagnostic reasoning are limited in their ability to perform complex tasks. |
| Approach: | They propose to benchmark diagnostic capabilities of large language models to assess their accuracy and generalization bottlenecks. |
| Outcome: | The proposed model achieves 45.82%, 31.09%, and 17.79% accuracy, compared to current models, o3-mini, e1 and DeepSeek-R1 . |
LLM Sensitivity Evaluation Framework for Clinical Diagnosis (2025.coling-main)
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| Challenge: | Existing studies on the sensitivity of Large Language Models (LLMs) to irrelevant contexts neglect the importance of key information. |
| Approach: | They investigate the sensitivity of large language models to key medical information by introducing different perturbation strategies to investigate their sensitivity. |
| Outcome: | The proposed models are based on three LLMs, namely GPT-3.5, GPT-4, Gemini, Claude3 and LLaMA2-7b, and demonstrate their reliability and sensitivity to medical information. |
MEDDxAgent: A Unified Modular Agent Framework for Explainable Automatic Differential Diagnosis (2025.acl-long)
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Daniel Philip Rose, Chia-Chien Hung, Marco Lepri, Israa Alqassem, Kiril Gashteovski, Carolin Lawrence
| Challenge: | Existing approaches to DDx are limited by single-dataset evaluations, isolated optimization of components, unrealistic assumptions about complete patient profiles, and single-attempt diagnosis. |
| Approach: | They propose a Modular Explainable DDx Agent framework that allows physicians to iteratively refine a ranked list of possible diseases based on symptoms, antecedents, and medical knowledge. |
| Outcome: | The proposed framework achieves over 10% accuracy improvements in interactive DDx across large and small LLMs while offering critical explainability into its diagnostic reasoning process. |
Beyond the Individual: Virtualizing Multi-Disciplinary Reasoning for Clinical Intake via Collaborative Agents (2026.findings-acl)
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Huangwei Chen, Wu Li, Junhao Jia, Yining Chen, Xiaotao Pang, Ya-Long Chen, Li Gonghui, Haishuai Wang, Jiajun Bu, Lei Wu
| Challenge: | Initial outpatient consultations are costly and difficult to scale to real-time intake. |
| Approach: | They propose a synchronous virtual MDT framework that formalizes the consultation state using a structured SOAP representation, separating evidence collection from diagnostic reasoning to improve traceability and bias control. |
| Outcome: | The proposed framework outperforms state-of-the-art models on ClinicalBench and a real-world RAPID-IPN dataset in documentation quality and consultation capability. |
PsyPath: Psychologically-guided Self-Exploration for Personality Detection (2026.findings-acl)
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| Challenge: | Personality detection aims to label traits via identifying linguistic cues from written text. |
| Approach: | They propose a framework that allows large language models to generate and answer psychologically meaningful questions and a hybrid scoring mechanism to evaluate the generated nodes in the reasoning paths. |
| Outcome: | The proposed framework outperforms baselines on two benchmark datasets and significantly improves performance and interpretability in downstream tasks. |
Strong Reasoning Isn’t Enough: Evaluating Evidence Elicitation in Interactive Diagnosis (2026.findings-acl)
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| Challenge: | Existing evaluations of medical consultation are static or outcome-centric, neglecting the evidence-gathering process. |
| Approach: | They propose an interactive evaluation framework that explicitly models the consultation process using a simulated patient and a measurement module grounded in atomic evidences. |
| Outcome: | The proposed evaluation framework outperforms baseline evaluation methods in medical consultation settings. |
MultiDx: A Multi-Source Knowledge Integration Framework towards Diagnostic Reasoning (2026.findings-acl)
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Yimin Deng, Zhenxi Lin, Yejing Wang, Guoshuai Zhao, Pengyue Jia, Zichuan Fu, Derong Xu, Yefeng Zheng, Xiangyu Zhao, Li Zhu, Xian Wu, Xueming Qian
| Challenge: | Existing approaches focus on diagnostic reasoning based on internal model knowledge or static knowledge bases. |
| Approach: | They propose a two-stage diagnostic reasoning framework that integrates multi-perspective evidence to generate a diagnostic prediction. |
| Outcome: | The proposed method generates suspected diagnoses and reasoning traces from web search, SOAP-formatted case, and clinical case database. |
Dr. Assistant: Enhancing Clinical Diagnostic Inquiry via Structured Diagnostic Reasoning Data and Reinforcement Learning (2026.findings-acl)
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Yue Guo, Fanfu Wang, Jianwei Lv, Xincheng Shi, Yuchen Li, Youya Wang, Yunsheng Zeng, Yujing Liu, Yunhao Qiao, Gen Li, Junfeng Wang, Bo Yuan
| Challenge: | Clinical Decision Support Systems (CDSSs) provide reasoning and inquiry guidance for physicians, yet they face high maintenance costs and low generalization capability. |
| Approach: | They propose a clinical diagnostic model with clinical reasoning and inquiry skills, the Dr. Assistant, and a pipeline to capture abstract reasoning logic. |
| Outcome: | The proposed model outperforms open-source models and achieves competitive performance to closed-source model. |
Dialectic-Med: Mitigating Diagnostic Hallucinations via Counterfactual Adversarial Multi-Agent Debate (2026.findings-acl)
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| Challenge: | Existing Chain-of-Thought (CoT) approaches lack intrinsic correction mechanisms, rendering them vulnerable to error propagation. |
| Approach: | They propose a multi-agent framework that enforces diagnostic rigor through adversarial dialectics. |
| Outcome: | Empirical evaluations show that the proposed framework improves explanation faithfulness and mitigates hallucinations. |